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High Pressure Michael Addition Catalyzed by Fluoride Ions
Author(s) -
Matsumoto Kiyoshi
Publication year - 1981
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198107701
Subject(s) - catalysis , michael reaction , fluoride , chalcone , yield (engineering) , chemistry , ion , high pressure , medicinal chemistry , organic chemistry , inorganic chemistry , materials science , physics , metallurgy , engineering physics
The synthesis of compounds having quaternary C atoms by Michael addition is often unsuccessful if the donor reaction center has bulky substituents. However, under high pressure conditions and fluoride catalysis even e.g. chalcone reacts with diethyl isopropylmalonate and diethyl phenylmalonate in 20 and 24% yield, respectively.