Premium
Specific Separation of Products in Supported Oligonucleotide Syntheses Using the Triester Method
Author(s) -
Seliger Hartmut,
Görtz HansHelmut
Publication year - 1981
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198106831
Subject(s) - oligonucleotide , fragment (logic) , chemistry , nucleotide , chromatography , combinatorial chemistry , dna , biochemistry , computer science , algorithm , gene
The mixture of homologous nucleotide fragments usually formed during carrier‐oligonucleotide synthesis can be separated chromatographically so as to isolate the desired fragment, if the latter is protected at the 5′‐end with a hexadecyloxytrityl group (see (2) in the previous communication).