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Model Reactions for the Stereo‐Controlled Synthesis of Aminopolyols; Reduction of Isoxazolines with Free or Protected Hydroxy Groups in Position 4 or in Side Chains
Author(s) -
Jäger Volker,
Schwab Wilfried,
Buss Volker
Publication year - 1981
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198106011
Subject(s) - chemistry , side chain , hydride , asymmetric induction , reduction (mathematics) , sphingolipid , amino acid , stereochemistry , position (finance) , combinatorial chemistry , organic chemistry , catalysis , biochemistry , enantioselective synthesis , mathematics , hydrogen , polymer , geometry , finance , economics
The effects of substituents on asymmetric induction in hydride additions have been investigated on isoxazoline derivatives; the results, which are of importance for the synthesis of hydroxylated amino acids, sphingolipid bases or amino sugars, can be rationalized with the models (1) and (2) .