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A Simple Pyrrole Synthesis via an Unusually Facile 1,3 Shift in N ‐Benzyl‐ N ‐(2‐benzylaminocyclopropyl)‐ N ‐benzylideneammonium Ions
Author(s) -
Quast Helmut,
von der Saal Wolfgang,
Stawitz Josef
Publication year - 1981
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198105881
Subject(s) - pyrrole , chemistry , ring (chemistry) , ion , medicinal chemistry , combinatorial chemistry , organic chemistry
The key step of a new, simple synthesis of pyrrole from (substituted) 1,2‐bis(benzylamino)cyclopropanes and aromatic aldehydes is the ring expansion (1) → (2) . In the last step benzylammonium ions are cleaved off.
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