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Diastereoselective Synthesis of β‐Nitro‐ and β‐Aminoalcohols
Author(s) -
Seebach Dieter,
Beck Albert K.,
Lehr Friedrich,
Weller Thomas,
Colvin Ernest
Publication year - 1981
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198103971
Subject(s) - synthon , nitro , diastereomer , chemistry , protonation , lithium (medication) , organic chemistry , ion , alkyl , medicine , endocrinology
Almost pure diastereoisomers of β‐amino alcohols, important as synthons , can be prepared via the O ‐silylated nitroalcohols (1) . Compounds (1) are accessible by protonation of the corresponding lithium salts or by addition of silylated aci ‐nitro derivatives R 2 CH = NO 2 Si t BuMe 2 to aldehydes R 1 CHO.