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A Novel Method for Preparation of Ansapeptides; Synthesis of Model Peptide Alkaloids
Author(s) -
Schmidt Ulrich,
Griesser Helmut,
Lieberknecht Albrecht,
Talbiersky Jörg
Publication year - 1981
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198102801
Subject(s) - peptide , combinatorial chemistry , chemistry , stereochemistry , biochemistry
The preparation of 14‐membered peptide alkaloids was first investigated on model educts such as the pentafluorophenyl esters (1) , Z = benzyloxycarbonyl. On the basis of these investigations it was subsequently possible to develop a method for the synthesis of dihydrozizyphin G (2) , AA = CH 2 CH 2 , as the first compound of this type.