Premium
Protein Differentiation: Emergence of Novel Proteins during Evolution
Author(s) -
Schulz Georg E.
Publication year - 1981
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198101431
Subject(s) - gene duplication , gene , biology , ancestor , function (biology) , gene product , evolutionary biology , most recent common ancestor , genetics , computational biology , phylogenetics , gene expression , archaeology , history
The almost limitless number of proteins can be reduced to approximately 200 basic structures, i.e. geometries of polypeptide chains; these form, the set from which the tracable protein differentiation started. Protein differentiation begins with a gene duplication. One of the gene products is conserved since it must continue to fulfill the original function. The other gene product is conserved as soon as it has taken over a new function. Comparing amino acid sequences of equivalent proteins in two species yields the evolutionary distance between these species, which allows dating of their common ancestor (“molecular palaeontology”). These comparisons are now applied to the geometries of nonequivalent proteins, elucidating the pathways of protein differentiation.