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Structure of the Antibiotic Moenomycin A
Author(s) -
Welzel Peter,
Witteler FranzJosef,
Müller Dietrich,
Riemer Werner
Publication year - 1981
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198101211
Subject(s) - antibiotics , biosynthesis , chemistry , stereochemistry , microbiology and biotechnology , biochemistry , biology , enzyme
The coupling of the (known) structural units, A‐B‐C and D‐E‐F‐G‐H‐I in moenomycin, has been explained by a combination of degradation, and high resolution mass‐ and 1 H‐NMR‐spectroscopic studies. Moenomycin is one of the most active inhibitors of bacterial cell wall biosynthesis; now that the structure is known the determination of the important characteristics of its antibiotic activity should follow.