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Chemo‐ and Diastereoselective Addition of Alkyl‐ and Aryltitanium( IV ) Compounds to Aldehydes and Ketones
Author(s) -
Reetz Manfred T.,
Steinbach Rainer,
Westermann Jürgen,
Peter Roland
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198010111
Subject(s) - alkyl , alcohol , chemistry , ketone , medicinal chemistry , organic chemistry , aldehyde , catalysis
CC bond formation with organotitanium compounds has many advantages. Thus aldehydes react considerably faster than ketones: for instance, PhTi(O‐ i Pr) 3 gives > 90% of (1) , and 4‐ tert ‐butylcyclohexanone forms a 18:82 mixture of equatorial and axial alcohol (2) with Me 2 TiCl 2 .
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