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Chemoselective and Position Specific Methylation of tert ‐Alkyl Halides with Methyltitanium( IV ) Chlorides
Author(s) -
Reetz Manfred T.,
Westermann Jürgen,
Steinbach Rainer
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198009011
Subject(s) - alkyl , chemoselectivity , halide , methylation , chemistry , reagent , chloride , medicinal chemistry , organic chemistry , catalysis , biochemistry , gene
Methylation with methyltitanium reagents promises to have a wide range of application, not least because of its chemoselectivity. In the tert ‐alkyl chlorides studied, which additonally contained a primary ‐or sec ‐alkyl chloride unit or an olefinic double bond, only the tert ‐C‐atom was methylated under favorable conditions.