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Formation of Pyrrolnitrin and 3‐(2‐Amino‐3‐chlorophenyl)pyrrole from 7‐Chlorotryptophan
Author(s) -
van Pée KarlHeinz,
Salcher Olga,
Lingens Franz
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198008281
Subject(s) - metabolite , pyrrole , biosynthesis , chemistry , antifungal , connection (principal bundle) , metabolism , secondary metabolite , biochemistry , antibiotics , stereochemistry , biology , microbiology and biotechnology , organic chemistry , enzyme , gene , mathematics , geometry
Little is known about chlorinations in secondary metabolism. In connection with the biosynthesis of the antifungal antibiotic pyrrolnitrin (2) , NO 2 in place of NH 2 , the metabolite (2) has now been isolated for the first time. The intermediates (1) and (3) were elucidated on a previous occasion.