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New Prostacyclin Analogues
Author(s) -
Bartmann Wilhelm,
Beck Gerhard,
Knolle Jochen,
Rupp R. Helmut
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198008191
Subject(s) - prostacyclin , chemistry , stereochemistry , combinatorial chemistry , biochemistry
The highly active prostacyclin (1) cannot be used therapeutically owing to its extremely short half‐life (only 3 min in water at 37°C pH 7.5). Methyl esters of the three analogues having the partial structure (2) , X = O,S, and NH, have now been synthesized from an industrially available starting compound. The analogues exhibit interesting biological properties.