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Asymmetric Synthesis of Amines by Carbon‐Carbon Coupling in the α‐Position to Nitrogen
Author(s) -
Kolb Michael,
Barth Jacqueline
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198007251
Subject(s) - nitrogen , carbon fibers , optically active , asymmetric carbon , position (finance) , coupling (piping) , chemistry , reinforced carbon–carbon , amino acid , organic chemistry , combinatorial chemistry , stereochemistry , materials science , biochemistry , finance , composite number , economics , composite material , metallurgy
Optically active amines of type (3) and (4) from propargylamine (1) can be obtained by use of the chiral auxiliary compound (S)‐(2) ; the auxiliary compound is recycled in this synthesis. (3) and (4) can be transformed, for example, into amino acids and heterocycles.