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An Amino‐Protecting Group for Use in Peptide Synthesis Which Can Be Introduced Electrochemically
Author(s) -
Khalifa Mohamed Hassen,
Jung Günther,
Rieker Anton
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198007121
Subject(s) - racemization , hydrogenolysis , protecting group , selectivity , group (periodic table) , peptide , chemistry , peptide synthesis , combinatorial chemistry , organic chemistry , catalysis , biochemistry , alkyl
The new amino protecting group PChd has the following advantages: the N ‐(PChd) esters (3) are usually formed without racemization and in high selectivity; the group can be removed quantitatively by hydrogenolysis with regeneration of (1) (R C 6 H 5 ).
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