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Physicochemical Principles and Applications of Supercritical Fluid Chromatography (SFC). New analytical methods (19)
Author(s) -
van Wasen Ulrich,
Swaid Issam,
Schneider Gerhard M.
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198005753
Subject(s) - supercritical fluid chromatography , chromatography , chemistry , supercritical fluid , supercritical fluid extraction , gas chromatography , countercurrent chromatography , extraction (chemistry) , high performance liquid chromatography , organic chemistry
In supercritical fluid chromatography (SFC) compressed gases in the region of their critical temperature are used as mobile phases. SFC has important advantages over gas chromatography (GC) for the separation of low‐volatile or thermally unstable substances. Like high pressure liquid chromatography (HPLC) and gel chromatography, it is used for various special applications and preparative separations, e.g. in the petroleum industry and in the separation of oligomers. SFC is of great interest in fundamental research on fluid extraction and for the determination of the physicochemical properties of fluid systems. In this contribution the most important physicochemical, methodological, and instrumental principles of SFC are summarized; characteristic physicochemical applications are the determination of capacity ratios, partition coefficients, partial molar volumes, interaction second virial coefficients, and difusion coefficients.