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A Novel Entry to Brefeldin A
Author(s) -
Köksal Yetkin,
Raddatz Peter,
Winterfeldt Ekkehard
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198004721
Subject(s) - brefeldin a , cyclopentanone , chemistry , stereochemistry , organic chemistry , biochemistry , golgi apparatus , cell , catalysis
The total synthesis of the macrolide antibiotic brefeldin A (2) has been accomplished, starting from cyclopentenyl acetate (1) . Successive Michael addition to (1) permitted construction of the trans ‐disubstituted cyclopentanone system