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Structure of Yellow Metal‐Free and Yellow Cobalt‐Containing Corrinoids
Author(s) -
Schlingmann Gerhard,
Dresow Bernd,
Koppenhagen Volker B.,
Becker Wulf,
Sherldrick William S.
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198003212
Subject(s) - chemistry , ring (chemistry) , stereochemistry , cobalt , metal , organic chemistry
The biologically inactive yellow metal‐free corrinoids produced in large amounts by bacteria might be of use in the synthesis of vitamin B 12 antimetabolites. X‐ray structure analysis of a “yellow” Co(CN) 2 ‐containing model compound revealed that the side chain c forms a lactam ring. The yellow metal‐free corrinoids are probably similar in structure. Incorporation of Co and treatment with KCN transforms them into biologically active red corrinoids (with opening of the lactam ring).