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Synthesis of the Epimeric 4‐Methyl Derivatives of endo ‐ endo ‐ and exo ‐ endo ‐ Tetracyclo[6.2.1.1 3,6 .0 2,7 ]dodecane
Author(s) -
Lenoir Dieter,
Frank Robert M.
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198003181
Subject(s) - steric effects , stereochemistry , chemistry , nuclear magnetic resonance spectroscopy
A need for model compounds for examining steric hindrance in highly strained cycloaliphatic compounds prompted synthesis of compounds (1) and (2) and their isomers with exo ‐ endo instead of endo ‐ endo skeleton. The greater strain of (2) with inside methyl group is evident in the IR and NMR spectrum.