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Enantioselective Synthesis of α‐Methylserines
Author(s) -
Schöllkopf Ulrich,
Hartwig Wolfgang,
Groth Ulrich
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198002121
Subject(s) - enantioselective synthesis , optically active , hydrolysis , ether , chemistry , alanine , enzyme , stereochemistry , amino acid , organic chemistry , catalysis , biochemistry
Optically active amino acids not occurring in nature , are of interest, e.g. as potential enzyme inhibitors or as pharmaceuticals. Reaction of the lithiated lactim ether (1) obtainable from cyclo ‐( L ‐Ala‐ L ‐Ala) with carbonyl compounds and hydrolysis affords the α‐methylserines (2) (and alanine).