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Electrophilic Reagents—Recent Developments and Their Preparative Application
Author(s) -
Effenberger Franz
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198001513
Subject(s) - electrophile , reagent , trifluoromethanesulfonate , chemistry , friedel–crafts reaction , selectivity , lewis acids and bases , catalysis , reactivity (psychology) , combinatorial chemistry , organic chemistry , imidazole , pathology , medicine , alternative medicine
The most widely known electrophilic agents are protic acids and compounds with an electronsextet partial structure. Recent research has aimed at the development of new electrophilic reagents, with greater reactivity on the one hand and higher selectivity on the other, which would largely obviate the addition of Lewis acids (Friedel‐Crafts catalysts), and also allow control of the isomer ratio in reactions with ambivalent substrates. Compounds with “super‐leaving groups”, such as trifluoromethanesulfonate and fluorosulfate, have been demonstrated as most advantageous in this respect since they are sufficiently polarized or dissociated for reactions to take place even in the absence of Friedel‐Crafts catalysts. Heterocycles such as pyridones or imidazole are likewise suitable leaving groups; they are employed for their high selectivity, and also because they allow working under non‐aqueous conditions.