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Synthesis and Transformations of 5‐Cyano‐2,2,8,8,12,13,17,18‐octamethylisobacteriochlorin
Author(s) -
Naab Paul,
Lattmann René,
Angst Christof,
Eschenmoser Albert
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198001431
Subject(s) - substrate (aquarium) , catalysis , derivative (finance) , combinatorial chemistry , chemistry , ion , medicinal chemistry , stereochemistry , organic chemistry , oceanography , financial economics , economics , geology
A model substrate for studies in the hexahydroporphyrin series , i.e. the title compound (1) having C 2v symmetry, has been prepared by a multistep de‐novo synthesis from a cyanosubstituted thiolactam. Catalytic hydrogenation of (1) affords the highly O 2 ‐sensitive 2,3,7,8,15,24‐hexahydro derivative; attempts to incorporate metal ions into this species lead to complexes of the 1,2,3,7,8,20‐hexahydro isomer.