(3 R,S )‐3,4‐Dicarboxy‐3‐hydroxybutyl Coenzyme A, an Inhibitor of the Citrate Synthase Reaction | Zendy

Eggerer Hermann | Zendy; Giesemann Walter | Zendy; Aigner Horst | Zendy

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(3 R,S )‐3,4‐Dicarboxy‐3‐hydroxybutyl Coenzyme A, an Inhibitor of the Citrate Synthase Reaction

Author(s) -

Eggerer Hermann,

Giesemann Walter,

Aigner Horst

Publication year - 1980

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.198001361

Subject(s) - citrate synthase , coenzyme a , citric acid cycle , chemistry , acetyl coa , enzyme , cofactor , atp synthase , atp citrate lyase , biochemistry , tricarboxylic acid , stereochemistry , reductase

Citrate synthase, an enzyme of the tricarboxylic acid cycle , catalyzes the formation of citrate and coenzyme A from acetyl CoA and oxalacetate. In order to establish whether citryl CoA is formed as a true intermediate on the synthase, the analogue (1) , R 1 = CH 2 SCoA, R 2 = H, has been synthesized (citryl CoA contains CO in place of CH 2 ). Kinetic measurements showed that (1) acts as a strong inhibitor.

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