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New Peptide Synthesis
Author(s) -
Wissmann Hans,
Kleiner HanssJerg
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198001331
Subject(s) - peptide , chemistry , biochemistry
Alkylphosphonic anhydrides such as (1) are recommended as condensation reagents for peptide synthesis. One advantage of (1) over dicyclohexylcarbodiimide (DCC) is that no sparingly soluble secondary products are formed. With regard to yield and degree of racemization, the new method is just as good as improved DCC techniques, and in some cases superior.