Premium
Functionalization of α‐Methylene Ketones
Author(s) -
Sander Jürgen,
Clauss Karl
Publication year - 1980
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.198001311
Subject(s) - surface modification , methylene , ring (chemistry) , chemistry , ketone , combinatorial chemistry , medicinal chemistry , organic chemistry
β‐Substituted acrylonitriles (4) and (5) are formed in a novel reaction from the oxathiazine derivatives (3) via ring opening and elimination of SO 3 . The reactants (3) are in turn accessible in several steps from the ketones (1) having an α‐CH 2 group. Step (2) → (3) is also new.