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Directed Synthesis of the Trimeric Isoadenylate A2′p5′A2′p5′A
Author(s) -
Engels Joachim,
Krahmer Ute
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197909421
Subject(s) - effector , chemistry , linkage (software) , isolation (microbiology) , combinatorial chemistry , stereochemistry , medicine , virology , biology , biochemistry , bioinformatics , gene
New impetus for virus therapy should come from the isolation of an isoadenylate with “unnatural” 2′‐5′ linkage from interferon‐treated cells. This effector molecule, the title compound, has now been synthesized on a gram scale from inexpensive adenosine.