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Quantitative Trace Analysis of Thallium in Biological Material
Author(s) -
Achenbach Christoph,
Ziskoven Rolf,
Koehler Ferdinand,
Bahr Ute,
Schulten HansRolf
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197908821
Subject(s) - thallium , pharmacokinetics , chemistry , fetus , tissue distribution , radiochemistry , mass spectrometry , pharmacology , medicine , chromatography , biology , pregnancy , inorganic chemistry , genetics
The pharmacokinetics of the poisonous element thallium have been examined directly by field desorption mass spectrometry from very small tissue samples. After oral administration of 160 mg/kg to mice, concentrations of 10 −4 mol/1 were found in organs. While the teratogenic dose 50% is lower than the lethal dose 50% by a factor of 40, some 12.5% of fetal malformations still occur at 1/1000 of the lethal dose.