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Enantioselective Synthesis of α‐Methyl‐α‐aminocarboxylic Acids by Alkylation of the Lactim Ether of cyclo ‐( L ‐Ala‐ L ‐Ala)
Author(s) -
Schöllkopf Ulrich,
Hartwig Wolfgang,
Groth Ulrich
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197908631
Subject(s) - enantioselective synthesis , alkylation , ether , chemistry , stereochemistry , organic chemistry , catalysis
Preparatively valuable asymmetric amino acid syntheses must be simple to carry out, give yields of >90%, and, where appropriate, permit recovery of the chiral auxiliary agent. These demands are met by the new synthesis via cyclo ‐( L ‐Ala‐ L ‐Ala).
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