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A Fragmentational Approach to Macrolides: (5‐ E , 8‐ Z )‐6‐methyl‐5,8‐undecadien‐11‐olide
Author(s) -
Sternbach Daniel,
Jaisli Fritz,
Bonetti Marco,
Eschenmoser Albert,
Shibuya Masayuki
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197906341
Subject(s) - diastereomer , lactone , chemistry , fragmentation (computing) , stereochemistry , salt (chemistry) , organic chemistry , biology , ecology
Decarboxylative double fragmentation of type A is the key step in the synthesis of the unsaturated lactone (2) from the amidinium salt (1) . The diastereomer of (1) also gives (2) . The isomeric lactone (3) can be obtained analogously from diastereomeric amidinium salts.
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