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Intramolecular Cl,H Disproportionation of an Oxamide Chloride. An Entry to Imidazole Derivatives
Author(s) -
Janousek Zdenek,
Huys Fabienne,
René Loïc,
Masquelier Michèle,
Stella Lucien,
Merényi Robert,
Viehe Heinz Günter
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197906161
Subject(s) - disproportionation , oxamide , intramolecular force , chemistry , imidazole , chloride , medicinal chemistry , salt (chemistry) , polymer chemistry , combinatorial chemistry , organic chemistry , catalysis
The key step of exhaustive chlorination of tetramethyldithiooxamide (1) , which surprisingly led to the new imidazolium salt (4) , is Cl,H disproportionation of (2) (capto‐dative substitution) to give (3) . Compound (2) , precipitates on chlorination of Me 2 NCCNMe 2 , but cannot be isolated.