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Metalation of Pyrans and Dihydropyridines: When is an 8 π‐System Cost Effective?
Author(s) -
Schlosser Manfred,
Schneider Philippe
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197904891
Subject(s) - metalation , chemistry , organometallic chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , catalysis
An organometallic 8 π system (2) could be generated by reaction of (1) with trimethylsilylmethylpotassium. The intermediate (2) is moderately stable at −50°C and reacts with MeI to give (3) and (4) . E Me (1:1), and with Me 3 SiCl to give (4) , E Me 3 Si.