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Titanocene Dichloride—The First Metallocene with Cancerostatic Activity
Author(s) -
Köpf Hartmut,
KöpfMaier Petra
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197904771
Subject(s) - metallocene , chemistry , therapeutic index , stereochemistry , combinatorial chemistry , organic chemistry , drug , pharmacology , biology , polymerization , polymer
The cancerostatic activity of metal complexes can be tested on mice by injection of tumor cells and, 24 h later, the substance to be investigated. Compound (1) , selected partly because of its structural similarity to the antitumor agent (2) , exhibited a cure rate of over 80% in the therapeutic range.
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