Premium
Key Building Blocks of Natural Product Biosynthesis and Their Significance in Chemistry and Medicine
Author(s) -
Franck Burchard
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197904291
Subject(s) - natural product , key (lock) , natural (archaeology) , biosynthesis , chemistry , product (mathematics) , biochemical engineering , biochemistry , combinatorial chemistry , computer science , biology , engineering , ecology , mathematics , enzyme , paleontology , geometry
Abstract The principle features of the biosynthesis of natural products have been elucidated during the past thirty years by the use of isotopic methods. It was discovered that large groups of natural products originate from the same biosynthetic precursor—the key building block. The conversion of key building blocks into biologically active natural products serves as a model for the development of more efficient syntheses in chemistry. In medicine, information about key building blocks permits the elucidation and therapy of metabolic diseases.