Premium
Selective Deuteration of Enamines with Deuterated Formic Acids
Author(s) -
Himmele Walter,
Bremser Wolfgang,
Siegel Hardo
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197903202
Subject(s) - enamine , chemistry , formic acid , deuterium , stereochemistry , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , physics , quantum mechanics
Selective isotopic lebeling is very important for elucidating the metabolites of active substances. It can be accomplished by reducing an enamine (R4‐ tert ‐butylbenzy) with HCOOD, DCOOD, or DCOOH, e.g.