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Lactide Contraction—A Method for the Synthesis of α,α′‐Dihydroxy Ketones from α‐Hydroxy Carboxylic Acids
Author(s) -
Schöllkopf Ulrich,
Hartwig Wolfgang,
Sprotte Uwe,
Jung Werner
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197903101
Subject(s) - synthon , contraction (grammar) , chemistry , carboxylic acid , alkyl , ketone , stereochemistry , organic chemistry , biology , endocrinology
Hydroxy ketones and dihydroxy ketones (4) , R 4 = alkyl, H, are versatile synthons. Key step in their formation from α‐hydroxy carboxylic acids and β‐bromo acyl cholorides via (1) is the contraction (2) → (3) .