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Ester and Lactone Formation with the Reagent 1,2‐Dihydro‐4,6‐dimethyl‐2‐thioxo‐3‐pyridinecarbonitrile
Author(s) -
Schmidt Ulrich,
Heermann Dieter
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197903082
Subject(s) - lactone , reagent , chemistry , organic chemistry , combinatorial chemistry
Transformation of long‐chain ω‐hydroxy acids into the macrolactone can be accomplished with the title compound. The disulfied derived therefrom is esterified with the acid to give (1) ; on heating (1) gives the lactone. The thiol esters (1) are less expensive and more readily accessible than comparably reactive lactone precursors.