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Molecular Structure of Phe 2 ‐TRH, an Analogue of Thyrotropin‐Releasing Hormone
Author(s) -
Stezowski John J.,
Bürvenich Claus,
Voelter Wolfgang
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197902251
Subject(s) - thyrotropin releasing hormone , chemistry , hormone , stereochemistry , proline , crystallography , biochemistry , amino acid
X‐Ray structure analysis of thyrotropin‐releasing hormone (TRH) has hitherto been precluded by the reluctance of TRH to crystallize. Suitable crystals of the closely related compounds Phe 2 ‐TRH have now been obtained. The structure of this compound is characterized by slight disorder (two conformations of the proline ring).