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C ‐Acylation under Virtually Neutral Conditions
Author(s) -
Brooks Dee W.,
Lu Linda D.L.,
Masamune Satoru
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197900722
Subject(s) - acylation , malonic acid , chemistry , base (topology) , salt (chemistry) , thiol , weak base , medicinal chemistry , organic chemistry , stereochemistry , catalysis , mathematics , mathematical analysis
Acylations is syntheses of natural products often have to be performed under very mild conditions. The neutral Mg salt of a malonic thiol half‐ester of type (1) permits acylation of imidazolides (Im=1‐imidazolyl) in practically neutral solution. Numerous acid‐ and base‐labile groups survive this treatment.