Premium
C ‐Acylation under Virtually Neutral Conditions
Author(s) -
Brooks Dee W.,
Lu Linda D.L.,
Masamune Satoru
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197900722
Subject(s) - acylation , malonic acid , chemistry , base (topology) , salt (chemistry) , thiol , weak base , medicinal chemistry , organic chemistry , stereochemistry , catalysis , mathematics , mathematical analysis
Acylations is syntheses of natural products often have to be performed under very mild conditions. The neutral Mg salt of a malonic thiol half‐ester of type (1) permits acylation of imidazolides (Im=1‐imidazolyl) in practically neutral solution. Numerous acid‐ and base‐labile groups survive this treatment.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom