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Preparative Scale Directed Resolution of Enantiomeric Amines via Liquid Chromatography of Diastereomeric 4‐Hydroxybutyramides
Author(s) -
Helmchen Günter,
Nill Günter
Publication year - 1979
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197900651
Subject(s) - diastereomer , enantiomer , chemistry , reagent , moiety , resolution (logic) , chromatography , organic chemistry , chromatographic separation , enantiomeric excess , combinatorial chemistry , high performance liquid chromatography , enantioselective synthesis , catalysis , artificial intelligence , computer science
The separation of enantiomeric amines (1) on a preparative scale can be carried out by the same principles as used in the separation of enantiomeric carboxylic acids. However, there is no simple access to amides bearing α‐substituents in the acidic moiety; the corresponding 2‐alkylbutyrolactones racemize. 3‐Substituted butyrolactones such as (2) proved to be suitable reagents.