Correlation of the Absolute Configuration of Chiral Epoxides by Complexation Chromatography; Synthesis and Enantiomeric Purity of (+)‐ and (−)‐1,2‐Epoxypropane | Zendy

Schurig Volker | Zendy; Koppenhöfer Bernhard | Zendy; Bürkle Waldemar | Zendy

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Correlation of the Absolute Configuration of Chiral Epoxides by Complexation Chromatography; Synthesis and Enantiomeric Purity of (+)‐ and (−)‐1,2‐Epoxypropane

Author(s) -

Schurig Volker,

Koppenhöfer Bernhard,

Bürkle Waldemar

Publication year - 1978

Publication title -

angewandte chemie international edition in english

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 0570-0833

DOI - 10.1002/anie.197809371

Subject(s) - absolute configuration , optical rotation , enantiomer , chemistry , enantiomeric excess , specific rotation , ring (chemistry) , nickel , chromatography , polar , stereochemistry , organic chemistry , enantioselective synthesis , catalysis , physics , astronomy

Chiroptical properties of chiral substrates can be determined by complexation chromatography. 10 ‐9 g of crude, non‐derivatized substance suffice for determination of optical purity; the rotation of the pure enantiomer need not be known. Moreover, the absolute configuration of three‐membered ring heterocycles can be deduced from their retention behavior on a special nickel complex with the aid of a quadrant rule for (1) , XNH, O, S.

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