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Correlation of the Absolute Configuration of Chiral Epoxides by Complexation Chromatography; Synthesis and Enantiomeric Purity of (+)‐ and (−)‐1,2‐Epoxypropane
Author(s) -
Schurig Volker,
Koppenhöfer Bernhard,
Bürkle Waldemar
Publication year - 1978
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197809371
Subject(s) - absolute configuration , optical rotation , enantiomer , chemistry , enantiomeric excess , specific rotation , ring (chemistry) , nickel , chromatography , polar , stereochemistry , organic chemistry , enantioselective synthesis , catalysis , physics , astronomy
Chiroptical properties of chiral substrates can be determined by complexation chromatography. 10 ‐9 g of crude, non‐derivatized substance suffice for determination of optical purity; the rotation of the pure enantiomer need not be known. Moreover, the absolute configuration of three‐membered ring heterocycles can be deduced from their retention behavior on a special nickel complex with the aid of a quadrant rule for (1) , XNH, O, S.