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Direct Formation of the α‐Ferrocenylisobutyl Cation from Ferrocene and Isobutyraldehyde
Author(s) -
Herrmann Rudolf,
Ugi Ivar
Publication year - 1978
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197806891
Subject(s) - isobutyraldehyde , chemistry , trifluoroacetic acid , ferrocene , yield (engineering) , condensation , stereoselectivity , component (thermodynamics) , organic chemistry , catalysis , materials science , electrochemistry , physics , electrode , metallurgy , thermodynamics
Chiral reference systems for asymmetric syntheses , e.g. peptide synthesis by stereoselective four‐component condensation, are now readily available. Ferrocene, isobutyraldehyde, and trifluoroacetic acid initially yield the cation (1) which is easily transformed into (2) , the reference system for the above‐mentioned synthesis.
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