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1,2,8,9‐Tetrahydrodicyclobuta[ b,g ]phenathrene and 1,2,7,8‐Tetrahydrodicyclobuta[ b,h ]phenanthrene, Potentially Carcinogenic Activated Hydrocarbons
Author(s) -
Perkins P.,
Vollhardt K. P. C.
Publication year - 1978
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197806151
Subject(s) - phenanthrene , chemistry , carcinogen , ring (chemistry) , phenanthrenes , medicinal chemistry , stereochemistry , organic chemistry
The strained‐ring activation of polycyclic aromatic compounds such as phenanthrene may modify not only their physical and chemical properties but also their mutagenicity: Phenanthrene is inactive in the Ames test, doubly activated (1) is weakly active, and the isomer (2) inactive.