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Cycloadditions with [ n ]Cyclophanes
Author(s) -
Noble KarlLudwig,
Hopf Henning,
Jones Maitland,
Kammula Seetha L.
Publication year - 1978
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197806021
Subject(s) - steric effects , benzene , diene , benzene derivatives , chemistry , component (thermodynamics) , medicinal chemistry , stereochemistry , organic chemistry , chemical synthesis , physics , biochemistry , natural rubber , in vitro , thermodynamics
Diels‐Alder reactions of benzene derivatives are very rare. However, sterically strained benzene rings like that in (1) can act as diene component: 1:1 addition with strong dienophiles leads to bridged barrelenes [ n = 7 or 8, RCF 3 or CN (only n = 8)].