Premium
Synthesis and Biological Properties of Prostaglandin Endoperoxides, Thromboxanes and Prostacyclins
Author(s) -
Nicolaou K. C.,
Gasic G. P.,
Barnette W. E.
Publication year - 1978
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197802933
Subject(s) - thromboxanes , prostacyclin , chemistry , prostaglandin , thromboxane , thromboxane a synthase , biochemistry , thromboxane a2 , arachidonic acid , medicine , platelet , receptor , enzyme
Prostaglandins continue to be a major and fast‐developing area of research in the chemical and biological sciences. Increasing evidence has recently prompted some researchers to suggest that the important physiological actions of these hormones are exerted by their unstable arachidonic acid pathway intermediates, the endoperoxides, thromboxanes, and prostacyclin. The importance of these substances in physiology and medicine and the challenge they pose to synthetic chemistry place them in the forefront of chemical and biochemical investigation. Current biological research has greatly benefited by synthetic advances which have made available large quantities of some of these naturally occurring intermediates and several analogs with increased stabilities. Following a brief review of the primary prostaglandins, the present article describes recent biosynthetic developments, partial and total syntheses of prostaglandin endoperoxide analogs, thromboxane B 2 , and prostacyclins, and the biological properties of these molecules.