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Phase‐Transfer Catalyzed Alkylation of diphenylphosphinic Amide—A New Versatile Synthesis of Primary and Secondary Amines
Author(s) -
Zwierzak Andrzej,
Podstawczyńska Iwona
Publication year - 1977
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197707021
Subject(s) - alkylation , amide , primary (astronomy) , catalysis , phase (matter) , chemistry , phase transfer catalyst , organic chemistry , combinatorial chemistry , astronomy , physics
A general synthesis of primary and secondary amines consists in the alkylation of diphenylphosphinic amide and N ‐alkyldiphenylphosphinic amide under the conditions of phase‐transfer catalysis. Removal of the protecting group is accomplished with HCI gas in THF.