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Investigations of Mitochondrial Adenine Nucleotide Translocation by Means of Nucleotide Analogs
Author(s) -
Schlimme Eckhard,
Boos Karl Siegfried,
Bojanovski Dubo,
Lüstorff Joachim
Publication year - 1977
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197706951
Subject(s) - adenine nucleotide translocator , nucleotide , chromosomal translocation , adenine nucleotide , ribose , atp–adp translocase , inner membrane , inner mitochondrial membrane , biochemistry , chemistry , substrate (aquarium) , mitochondrion , biophysics , mitochondrial carrier , stereochemistry , biology , bacterial outer membrane , enzyme , ecology , escherichia coli , gene
ATP and ADP are transferred across the inner mitochondrial membrane by means of a carrier (translocator), an inner membrane integral lipoprotein. Translocation of the adenine nucleotides occurs in two steps: specific binding and transport. By using substrate analogs with modified adenine, phosphate, or ribose moieties it is possible to check which structural properties of the substrate are essential for binding and transport.