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Total Synthesis of [ 14 C]‐ and [ 3 H]‐ Labeled Tripyrrole Precursors for Heme Biosynthesis
Author(s) -
Franck Burchard,
Fels Gregor,
Ufer Günter,
Rowold Arend
Publication year - 1977
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197706511
Subject(s) - biosynthesis , heme , chemistry , incubation , stereochemistry , biochemistry , enzyme
For studies on heme biosynthesis the biogenetically plausible tripyrroles (1) and (2) bearing 14 C and 3 H labels have now been synthesized in 20 steps (R = H). Joint incubation of (1) and (2) with hemolyzed duck blood revealed that both tripyrroles can be utilized for the biosynthesis of heme, admittedly with different efficiencies.