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Nickel( II )‐Catalyzed Synthesis of Pyrroles from 2 H ‐Azirines and Activated Ketones
Author(s) -
dos Santos Filho Pedro Faria,
Schuchardt Ulf
Publication year - 1977
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197706471
Subject(s) - catalysis , pyrrole , nickel , chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry
A new pyrrole synthesis , which is free from side‐reactions, uses azirines (1) and ketones (2) as starting materials. Given sufficient activation of (2) , it leads to very high yields of the pyrroles (3) even at room temperature.