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Repetitive Peptide Synthesis with Insoluble Polymer‐Bound Reagents and Solubilizing Macromolecular Peptide Carriers
Author(s) -
Heusel Gerhard,
Bovermann Günter,
Göhring Walter,
Jung Günther
Publication year - 1977
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197706421
Subject(s) - reagent , macromolecule , peptide , chemistry , elongation , peptide synthesis , combinatorial chemistry , polymer , side chain , biochemistry , organic chemistry , materials science , metallurgy , ultimate tensile strength
A new reaction cycle for chain elongation of peptides utilizes soluble peptide carriers and solid polymeric reagents. In the actual coupling step no side products are formed, nor do excess reagents have to be removed.