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Phosphoranes as Intermediates in the Michaelis‐Arbusov Reaction
Author(s) -
Bauer Gert,
Hägele Gerhard
Publication year - 1977
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197704771
Subject(s) - yield (engineering) , michaelis–menten kinetics , chemistry , reaction conditions , medicinal chemistry , organic chemistry , materials science , catalysis , enzyme assay , enzyme , metallurgy
Phosphoranes of type (1) (XCl, Br, I) can occur as intermediates in the Michaelis‐Arbusov reaction, as has now been demonstrated. Compounds (1) were prepared in almost quantitative yield and converted into the expected products.