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Absolute Configuration of the Cancerostatic S ()‐Cyclophosphamide
Author(s) -
Adamaik Dorota A.,
Kinas Ryszard,
Saenger Wolfram,
Stec Wojciech J.
Publication year - 1977
Publication title -
angewandte chemie international edition in english
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 0570-0833
DOI - 10.1002/anie.197703301
Subject(s) - absolute (philosophy) , absolute configuration , cyclophosphamide , medicine , chemistry , philosophy , stereochemistry , theology , chemotherapy
(+) and (−)‐Cyclophosphamide (1) differ in their cancerostatic activity. X‐Ray analysis has shown the (−)‐enantiomer with the higher therapeutic index to have the S configuration.